Three weeks are officially in the books, and now we turn the page to Week 4 of the 2025 college football season. Oddsmakers have released the early lines, with several marquee matchups highlighting the slate.

The biggest showdowns on the board include Michigan vs. Nebraska, Illinois vs. Indiana, and Auburn vs. Oklahoma. As always, lines involving FCS programs are generally posted later in the week once more betting information becomes available.

👉 Odds courtesy of BetOnline.

Spotlight Matchups

Michigan (-1) at Nebraska

One of the most intriguing games of the week, Michigan opens as a slight 1-point road favorite. Nebraska has been tough at home, and their physical brand of football could test Michigan’s depth in the trenches. Expect this line to move depending on injury updates and practice reports out of Lincoln.

• Key Angle: Nebraska has historically been a strong home underdog, while Michigan’s defense has been elite against the run. Bettors will watch if the Wolverines can force Nebraska into a one-dimensional passing game.

Illinois at Indiana (-5)

A classic Big Ten battle with plenty of postseason implications. Indiana is laying five points at home, but Illinois has shown flashes of explosiveness on offense that could keep them in striking distance.

• Key Angle: The Illini have struggled ATS (against the spread) in conference road games, while Indiana has quietly been solid at home in September matchups. This line could generate heavy two-way action.

Auburn at Oklahoma (-6½)

Auburn faces a tall task in Norman as the Sooners open 6.5-point favorites. Oklahoma has been rolling offensively, while Auburn’s defense has kept them competitive against elite competition. This matchup will be a battle of tempo — can Auburn slow down Oklahoma’s high-powered attack?

• Key Angle: Auburn’s offense has been inconsistent, and if they can’t convert on third downs, the Sooners may cover this spread with ease. Conversely, if Auburn establishes the run, this game could stay closer than expected.

Thursday, September 18, 2025

• Rice (-4½) at Charlotte

Friday, September 19, 2025

• Tulsa at Oklahoma State (-13½)

• Iowa (-2) at Rutgers

Saturday, September 20, 2025

• Syracuse at Clemson (-17)

• Texas Tech at Utah (-4)

• Arkansas (-6) at Memphis

• Maryland at Wisconsin (-7)

• SMU at TCU (-6½)

• Bowling Green at Louisville (-27)

• UNLV (-4) at Miami (OH)

• North Texas at Army (-2½)

• UAB at Tennessee (-38)

• Oregon State at Oregon (-35)

• Purdue at Notre Dame (-26½)

• Kent State at Florida State (-43½)

• Tulane at Ole Miss (-12½)

• North Carolina at UCF (-6½)

• Ball State at UConn (-20½)

• James Madison (-10½) at Liberty

• Louisiana (-3) at Eastern Michigan

• Troy at Buffalo (-7)

• Toledo (-13½) at Western Michigan

• NC State at Duke (-3)

• Northern Illinois at Mississippi State (-21½)

• Temple at Georgia Tech (-24)

• West Virginia at Kansas (-13)

• Delaware at Florida International (-4½)

• Arkansas State (-7) at Kennesaw State

• South Carolina at Missouri (-12)

• Marshall (-3) at Middle Tennessee

• Nevada at Western Kentucky (-11½)

• Boise State (-8½) at Air Force

• Coastal Carolina at South Alabama (-14½)

• Florida at Miami (-9)

• Georgia State at Vanderbilt (-27)

• Washington (-19½) at Washington State

• Stanford at Virginia (-15)

• Arizona State at Baylor (-1½)

• BYU (-7) at East Carolina

• Southern Miss at Louisiana Tech (-1½)

• Sam Houston at Texas (-40½)

• UL Monroe at UTEP (-5)

• UTSA (-4½) at Colorado State

• Wyoming at Colorado (-13½)

• California (-13) at San Diego State

• Michigan State at USC (-16½)

• Fresno State (-3½) at Hawai’i

Where to Bet and Get More Information

If you’re looking to get in on the action, you can place wagers at BetOnline, one of the industry’s most trusted sportsbooks.

For premium betting picks from the pros, head to OffshoreInsiders.com.

And to shop the best lines, track odds movement, and monitor late-breaking injury news, check out OddsLogic.

Final Thoughts

Week 4 offers bettors a loaded board with everything from high-profile conference clashes to non-conference mismatches. Whether you’re zeroing in on underdog value or monitoring heavy favorites like Florida State, Georgia, and Oregon, it’s a week with plenty of betting opportunities.

Stay tuned as additional lines — particularly for FCS matchups — are released throughout the week.