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Ohio State vs. Indiana Betting Preview Big 10 Championship 2025
Dec 1st, 2025


Market snapshot

  • Matchup: No. 1 Ohio State vs No. 2 Indiana – Big Ten Championship

  • Location: Lucas Oil Stadium (Indy – indoors, neutral but Big Ten country)

  • Current line (DraftKings / consensus):

    • Spread: Ohio State -5.5

    • Total: 48.5–49.5

    • Moneyline: OSU ~-218, IU +180 (SI)

  • Kick: Saturday, Dec. 6, 8 p.m. ET (DraftKings Network)


Team résumés

Ohio State

  • Record: 12–0 (9–0 Big Ten), defending national champs, No. 1 AP. (Sports Reference)

  • Scoring offense / defense: ~37.9 ppg scored, 7.6 ppg allowed (No. 1 scoring D nationally). (NCAA.com)

  • ATS: 10–2 ATS; favored in every game, routinely laying big numbers. (SI)

  • Last game: 27–9 at Michigan as -10, snapped multi-year skid and clinched division. (Ohio State)

  • Head coach: Ryan Day.

  • Key skill guys:

    • QB Julian Sayin – ~3,065 pass yards, true downfield threat. (ESPN.com)

    • RB Bo Jackson – just under 1,000 rush yards. (ESPN.com)

    • WR Jeremiah Smith – primary explosive target. (ESPN.com)

Indiana

  • Record: 12–0 (9–0 Big Ten); first Big Ten title appearance ever, first 12–0 season in program history. (Sports Reference)

  • Scoring profile: Around 44.3 ppg scored, 10.9 ppg allowed, +33.4 margin of victory – best differential in FBS. (Warren Nolan)

  • ATS: 7–5 ATS; has covered as a dog (notably at Oregon) but occasionally overpriced as a big chalk. (SI)

  • Signature wins: at Oregon (30–20 as +6.5), at Iowa, at Penn State. (SI)

  • Head coach: Curt Cignetti (Year 2; program completely flipped). (Wikipedia)

  • Key skill guys:

    • QB Fernando Mendoza – Heisman favorite, 2,758 pass yards, 32 pass TD, 5 INT, plus 6 rush TD. (The Crimson Quarry)

    • RB Roman Hemby – team’s lead back, big factor in recent ground-heavy blowouts. (The Crimson Quarry)


Heisman & narrative angles

  • This is essentially a Mendoza (Indiana) vs Sayin (OSU) Heisman showcase. Heisman odds currently: Mendoza slight favorite (~+115), Sayin close behind (~+155). (The Crimson Quarry)

  • A big performance by either QB in prime time can swing both Heisman voting and CFP seeding; you can expect both staffs to keep starters aggressive deeper into the game than a typical OSU blowout.


Location / “travel” notes

  • Ohio State → Lucas Oil Stadium: ~176–178 miles from Columbus (about a 3-hour drive). (Travelmath)

  • Indiana → Lucas Oil Stadium: ~50–51 miles from Bloomington (under an hour). (Rome2Rio)

  • True neutral field in theory, but IU is the “home-state” team; OSU travels incredibly well, so crowd probably close to 50/50 with maybe a slight OSU edge in sheer numbers but more local noise for IU.


Matchup notes – when Ohio State has the ball

  • OSU offense vs IU defense

    • Ohio State is efficient and balanced; Sayin pushes it vertically but they’ve comfortably leaned on the run with a lead. (ESPN.com)

    • Indiana’s defense allows ~252 yards per game and just 4.48 yards per play – far better than the brand name might suggest. (CFB Stats)

    • Indiana’s split stats: they’ve still been solid on the road/neutral (~292 yds allowed per game), so there’s no huge “home only” mirage. (CFB Stats)

  • Key angles

    • If Indiana gets OSU in obvious passing downs, their 4–2–5 looks can disguise pressure and force Sayin into riskier throws – note he’s thrown picks in his last two road/neutral games. (CBS Sports)

    • OSU has been excellent at front-running: when they lead at half, the defense sits on opponents and games often die under the number.


Matchup notes – when Indiana has the ball

  • IU offense vs OSU defense

    • Indiana is an explosive spread outfit; the downfield passing game and RPOs have shredded most Big Ten defenses. (Wikipedia)

    • Film/charting: IU’s downfield pass success rate sits around 55% vs four-man rush, dropping into the high-30s when defenses blitz and get home. (Addicted To Quack)

    • Ohio State’s defense is elite at generating pressure with four and playing sticky coverage behind it – that’s structurally the right way to defend this offense. (NCAA.com)

  • Key angles

    • If OSU can create 2–3 obvious passing-down sacks/holding calls, that kills drives and favors the favorite/under.

    • If Indiana protects Mendoza and OSU can’t get heat without blitzing, IU’s explosive pass game can flip the script and make the +5.5 live all night.


ATS & total tendencies

  • Ohio State ATS: 10–2 ATS, including an easy cover at Michigan last week; only non-covers were vs Ohio and at Purdue as massive chalk. (SI)

  • Indiana ATS: 7–5 ATS; the market occasionally inflated their number vs mid-tier Big Ten teams, but they’ve answered in step-up games (Oregon, Penn State). (SI)

  • Totals:

    • Indiana has gone over in 8 of 12 games – largely because their offense keeps scoring late. (SI)

    • A major model (SportsLine) leans Indiana +5.5 and Under 48.5, with the Under hitting in nearly 70% of sims. (CBS Sports)

    • Indoors, but both teams have championship-level defenses, so this is not a typical “Big 12-style” shootout setup.


Situational / intangible notes

  • OSU off emotional revenge: Massive emotional peak vs Michigan, on the road, finally getting over the hump; classic spot where some bettors look to fade the favorite in a neutral title game the following week.

  • Indiana in program “Super Bowl” spot: First-ever appearance in Indy, 12–0, coaching staff pushing the “no one believes in us” angle. Early-game script likely aggressive.

  • Series history: OSU has won 30 straight vs IU; last Hoosier win was 1988. The line is telling you this is not your grandfather’s Indiana. (DraftKings Network)


How you might frame it on your card

You can slice this a bunch of ways, but structurally:

  • Case for Ohio State -5.5

    • Best defense in the country by scoring and among the top in yards/play allowed. (NCAA.com)

    • Elite ATS profile (10–2) despite constant tax. (SI)

    • Defensive front matches up well with what bothers Indiana’s passing game (pressure with four, coverage-heavy behind). (Addicted To Quack)

  • Case for Indiana +5.5

    • Point differential actually better than OSU’s; Hoosiers have obliterated most of the schedule. (Warren Nolan)

    • Heisman-favorite QB with legit weapons and a run game that just hung 355 rushing yards at Purdue. (The Crimson Quarry)

    • Neutral/indoor environment only ~50 miles from campus; no hostile-road factor. (Rome2Rio)

    • Popular computer model (SportsLine) prefers IU to cover and leans Under – so there’s at least some “model support” for dog + under correlation. (CBS Sports)

  • Total angle

    • Two top-tier defenses, both capable of compressing the red zone. If either staff turtles on 4th-and-short in plus territory, it naturally leans Under.

    • Counterpoint: high-leverage Heisman/CFP stakes could keep both coaches aggressive late, which is the main Over path.


Great sources

Posted by Elton Maloney (Profile) | Permalink | Comments (0) | Trackbacks (0)
Advisor to Joe Duffy's Picks as far as organic handicapping. An expert on matchups and other statistical analysis and research.
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